PSPC1

Across TCGA cell cohorts, PSPC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,526 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PSPC1-associated GO terms across cancer lineages are Positive regulation of DNA recombination, Regulation of double-strand break repair via homologous recombination, and Negative regulation of DNA-templated DNA replication. Each is linked with PSPC1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PSPC1-to-partner and partner-to-PSPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA recombination grouped by PSPC1-low versus PSPC1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PSPC1→partner) and Y-score (partner→PSPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of DNA recombination →	+0.103	+0.849	<.001	.001	3	13
SOFT_TISSUE	Regulation of double-strand break repair via homologous recombination →	+0.096	+0.924	<.001	<.001	3	13
SOFT_TISSUE	Negative regulation of DNA-templated DNA replication →	+0.128	+0.941	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	DNA integrity checkpoint signaling →	+0.074	+0.905	<.001	<.001	3	12
BONE	DNA strand elongation →	+0.176	+0.953	<.001	<.001	3	12
BONE	Protein-DNA complex disassembly →	+0.128	+0.657	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,526 associations by consensus.

Positive regulation of DNA recombination by PSPC1 expression — BONE

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