PSPC1

Across TCGA cell cohorts, PSPC1 mutation is significantly associated with the drug of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PSPC1-associated genes across cancer lineages are Nutlin-3a (-), Bromosporine, and Quizartinib. Each is linked with PSPC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSPC1-to-partner and partner-to-PSPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nutlin-3a (-) grouped by PSPC1-low versus PSPC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSPC1→partner) and Y-score (partner→PSPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Nutlin-3a (-) →	+0.731	+2.646	.047	.047	3	1
LARGE_INTESTINE	Bromosporine →	+0.401	+2.649	.019	.046	3	1
LARGE_INTESTINE	Quizartinib →	+0.496	+2.652	.001	.045	3	1
LARGE_INTESTINE	BIX02189 →	+0.422	+2.652	.036	.045	3	1
LARGE_INTESTINE	Fedratinib →	+0.531	+2.652	.043	.045	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.293	+2.649	.038	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Nutlin-3a (-) by PSPC1 expression — LARGE_INTESTINE

Explore this box plot interactively →