PSMG4

Across TCGA pan-cancer cohorts, PSMG4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PSMG4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PSMG4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PSMG4 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

COAD, LIHC, and KIRC are the cancer types where PSMG4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMG4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.292	<.001	11	view →
LIHC	Male	II,III,IV	+0.895	<.001	9	view →
KIRC	All	All	+0.183	<.001	9	view →
STAD	Male	II,III,IV	+0.678	<.001	8	view →
THCA	Male	All	−0.439	<.001	8	view →
HNSC	Male	III,IV	+0.432	<.001	8	view →
LUAD	All	All	+0.340	<.001	6	view →
READ	All	All	+0.718	.001	5	view →
BLCA	All	All	+0.444	.010	5	view →
CHOL	Male	All	+1.178	<.001	4	view →
LUSC	All	All	+0.249	.002	4	view →
BRCA	Female	II,III,IV	−0.195	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PSMG4–COAD

Open the COAD breakdown →