PSMG3

Across TCGA pan-cancer cohorts, PSMG3 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PSMG3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PSMG3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PSMG3 is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

COAD, PDAC, and LUAD are the cancer types where PSMG3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMG3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+0.339	<.001	8	view →
PDAC	Male	II,III,IV	+0.637	<.001	6	view →
LUAD	All	II,III,IV	+0.163	.001	6	view →
LSCC	Male	All	+0.153	.001	4	view →
CCRCC	Male	All	−0.145	.001	4	view →
OV	All	All	+0.547	.021	2	view →
HNSC	Male	All	−0.112	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PSMG3–COAD

Open the COAD breakdown →