PSMG3

Across TCGA patient cohorts, PSMG3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMG3-associated genes across cancer lineages are Gab2, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with PSMG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMG3-to-partner and partner-to-PSMG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by PSMG3-low versus PSMG3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMG3→partner) and Y-score (partner→PSMG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.566	+3.000	.006	.037	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.570	-2.986	.028	.037	3	1
UCEC	PDCD4 →	-0.754	-3.000	.005	.037	3	1
UCEC	NDRG1_pT346 →	-0.630	-3.000	.026	.037	2	1
UCEC	A-Raf_pS299 →	-0.192	-3.000	.005	.037	1	1
UCEC	E-Cadherin →	-0.688	-3.000	.014	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Gab2 by PSMG3 expression — UCEC

Explore this box plot interactively →