PSMF1

Across TCGA patient cohorts, PSMF1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMF1-associated genes across cancer lineages are JNK2, MEK1, and Notch1. Each is linked with PSMF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMF1-to-partner and partner-to-PSMF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PSMF1-low versus PSMF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMF1→partner) and Y-score (partner→PSMF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.276	+3.026	.001	.018	3	1
UCEC	MEK1 →	+0.458	+2.906	.003	.001	3	1
UCEC	Notch1 →	+0.126	+1.884	.034	.030	3	1
UCEC	p62 Lck ligand →	+0.402	+2.469	.003	.010	3	1
UCEC	PDCD4 →	-0.619	-2.222	.001	.011	3	1
UCEC	STAT3_pY705 →	-0.397	-1.700	<.001	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

JNK2 by PSMF1 expression — UCEC

Explore this box plot interactively →