PSME4

Across TCGA pan-cancer cohorts, PSME4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PSME4 data layer compared with 23 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PSME4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PSME4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where PSME4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	1.000	0.348	.002	24	view →
PDAC	DFS	Quartile	All	0.646	0.868	.015	13	view →
CCRCC	DFS	Median	III,IV	0.414	0.747	.006	12	view →
LUAD	DFS	Tertile	All	0.680	0.836	.010	11	view →
HNSC	DFS	Median	All	0.698	1.000	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PSME4–UCEC (OS)

Open the UCEC breakdown →