PSME4

Across TCGA patient cohorts, PSME4 protein abundance is significantly associated with the RNA expression of many other genes, with 18,032 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PSME4-associated genes across cancer lineages are CENPA, KPNA2, and MYBL2. Each is linked with PSME4 in more than 8 cancer types. Because this analysis shows association rather than direction, both PSME4-to-partner and partner-to-PSME4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PSME4 versus CENPA in LUAD, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSME4→partner) and Y-score (partner→PSME4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CENPA →	+1.308	+0.267	<.001	<.001	3	9
HNSC	KPNA2 →	+1.067	+0.297	<.001	<.001	3	9
LUAD	MYBL2 →	+1.512	+0.280	<.001	<.001	3	8
LUAD	KIF23 →	+1.119	+0.258	<.001	<.001	3	8
LUAD	CEP55 →	+1.199	+0.249	<.001	<.001	3	8
LUAD	CDK1 →	+1.103	+0.256	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,032 associations by consensus.

PSME4 vs CENPA — LUAD

Explore this scatter interactively →