PSME4

Across TCGA patient cohorts, PSME4 mutation is significantly associated with the RNA expression of many other genes, with 5,257 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSME4-associated genes across cancer lineages are CCM2L, GLRX3, and ZNHIT6. Each is linked with PSME4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PSME4-to-partner and partner-to-PSME4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCM2L grouped by PSME4-low versus PSME4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSME4→partner) and Y-score (partner→PSME4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCM2L →	-0.386	-1.467	<.001	<.001	3	4
UCEC	GLRX3 →	+0.439	+1.520	<.001	<.001	3	4
UCEC	ZNHIT6 →	+0.242	+1.536	.009	.008	3	4
UCEC	EMC4 →	+0.381	+2.528	<.001	<.001	3	4
UCEC	CCDC59 →	+0.430	+2.136	<.001	<.001	3	4
UCEC	MMS22L →	+0.336	+1.362	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,257 associations by consensus.

CCM2L by PSME4 expression — UCEC

Explore this box plot interactively →