PSME4

Across TCGA patient cohorts, PSME4 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSME4-associated genes across cancer lineages are p70-S6K, Rictor_pT1135, and JNK_pT183_Y185. Each is linked with PSME4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PSME4-to-partner and partner-to-PSME4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by PSME4-low versus PSME4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSME4→partner) and Y-score (partner→PSME4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	p70-S6K →	+0.393	+2.828	.002	.033	3	4
UCEC	Rictor_pT1135 →	-0.082	-1.392	.004	.017	3	4
STAD	JNK_pT183_Y185 →	-0.177	-2.978	.002	.036	3	3
STAD	PCNA →	+0.387	+3.000	.009	.034	2	4
UCEC	Cyclin-B1 →	+0.620	+1.678	<.001	<.001	3	3
UCEC	Notch1 →	+0.178	+1.678	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

p70-S6K by PSME4 expression — STAD

Explore this box plot interactively →