PSME4

Across TCGA cell cohorts, PSME4 mutation is significantly associated with the mutation status of many other genes, with 4,904 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PSME4-associated genes across cancer lineages are NRXN1, TSHZ2, and NCOR2. Each is linked with PSME4 in more than 5 cancer types. Because this analysis shows association rather than direction, both PSME4-to-partner and partner-to-PSME4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NRXN1 grouped by PSME4-low versus PSME4-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSME4→partner) and Y-score (partner→PSME4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NRXN1 →	+5.095	+4.442	.001	.001	1	6
LUNG_NSCLC_LUAD	TSHZ2 →	+2.670	+3.165	.004	.004	1	6
UPPER_AERODIGESTIVE_TRACT	NCOR2 →	+4.539	+5.193	<.001	<.001	1	6
SOFT_TISSUE	TNC →	+4.502	+5.066	.007	.007	1	6
LARGE_INTESTINE	BSN →	+1.502	+1.823	<.001	<.001	1	6
BLOOD_Leukemia	WNK1 →	+3.313	+5.326	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,904 associations by consensus.

NRXN1 by PSME4 expression — BREAST

Explore this box plot interactively →