PSME3

Across TCGA patient cohorts, PSME3 mutation is significantly associated with the RNA expression of many other genes, with 3,385 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSME3-associated genes across cancer lineages are RNU6-718P, HNRNPRP2, and MIR6749. Each is linked with PSME3 in more than 3 cancer types. Because this analysis shows association rather than direction, both PSME3-to-partner and partner-to-PSME3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-718P grouped by PSME3-low versus PSME3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSME3→partner) and Y-score (partner→PSME3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-718P →	+0.134	+3.462	.001	.002	3	4
CESC	HNRNPRP2 →	+0.047	+4.969	<.001	.004	3	2
CESC	MIR6749 →	+0.371	+5.342	<.001	.002	3	2
BLCA	USP9YP2 →	+0.039	+7.640	<.001	.009	3	2
SKCM	RNU1-27P →	+0.199	+4.097	<.001	.002	3	2
SKCM	GCSHP2 →	+0.060	+3.578	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,385 associations by consensus.

RNU6-718P by PSME3 expression — UCEC

Explore this box plot interactively →