PSME3

Across TCGA cell cohorts, PSME3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,568 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PSME3-associated GO terms across cancer lineages are rRNA 5'-end processing, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Maturation of SSU-rRNA. Each is linked with PSME3 in more than 15 cancer types. Because this analysis shows association rather than direction, both PSME3-to-partner and partner-to-PSME3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA 5'-end processing grouped by PSME3-low versus PSME3-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PSME3→partner) and Y-score (partner→PSME3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	rRNA 5'-end processing →	+0.138	+0.801	.004	.005	3	16
BLOOD_Myeloma	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.138	+0.801	.004	.005	3	16
BLOOD_Lymphoma	Maturation of SSU-rRNA →	+0.124	+0.975	<.001	<.001	3	15
BLOOD_Lymphoma	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.115	+0.906	<.001	<.001	3	15
BLOOD_Myeloma	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.146	+0.712	<.001	.004	3	15
CNS	Positive regulation of mRNA splicing, via spliceosome →	+0.115	+0.598	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,568 associations by consensus.

rRNA 5'-end processing by PSME3 expression — BLOOD_Myeloma

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