PSME2

Across TCGA patient cohorts, PSME2 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSME2-associated genes across cancer lineages are EGFR, eIF4G, and JNK_pT183_Y185. Each is linked with PSME2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSME2-to-partner and partner-to-PSME2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by PSME2-low versus PSME2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSME2→partner) and Y-score (partner→PSME2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.264	-3.169	.002	.020	3	1
UCEC	eIF4G →	+0.484	+3.169	.004	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.197	-3.000	.033	.036	3	1
UCEC	mTOR_pS2448 →	-0.170	-2.980	.037	.036	3	1
UCEC	AMPK_alpha →	-0.254	-3.000	.015	.036	3	1
UCEC	PKC-b-II_pS660 →	-0.386	-3.000	.010	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR by PSME2 expression — UCEC

Explore this box plot interactively →