PSME1

Across TCGA patient cohorts, PSME1 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSME1-associated genes across cancer lineages are Epithelial cells, mv Endothelial cells, and Basophils. Each is linked with PSME1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSME1-to-partner and partner-to-PSME1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epithelial cells grouped by PSME1-low versus PSME1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSME1→partner) and Y-score (partner→PSME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Epithelial cells →	-0.148	-2.989	<.001	.035	3	1
UCEC	mv Endothelial cells →	-0.030	-3.000	.019	.036	3	1
UCEC	Basophils →	+0.206	+3.169	.027	.020	3	1
UCEC	pDC →	+0.053	+3.180	.048	.010	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Epithelial cells by PSME1 expression — UCEC

Explore this box plot interactively →