PSME1

Across TCGA cell cohorts, PSME1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,287 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PSME1-associated GO terms across cancer lineages are Negative regulation of viral genome replication, CD8-positive, alpha-beta T cell homeostasis, and Negative regulation of viral process. Each is linked with PSME1 in more than 13 cancer types. Because this analysis shows association rather than direction, both PSME1-to-partner and partner-to-PSME1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of viral genome replication grouped by PSME1-low versus PSME1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PSME1→partner) and Y-score (partner→PSME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of viral genome replication →	+0.165	+1.200	<.001	<.001	3	14
URINARY_TRACT	CD8-positive, alpha-beta T cell homeostasis →	+0.156	+0.895	.003	.001	3	13
SOFT_TISSUE	Negative regulation of viral process →	+0.135	+1.301	<.001	<.001	3	13
URINARY_TRACT	Negative regulation of regulatory T cell differentiation →	+0.211	+0.971	.002	.004	3	13
PANCREAS	Negative regulation of response to biotic stimulus →	+0.080	+0.758	.001	<.001	3	12
PANCREAS	Positive regulation of chromatin binding →	+0.255	+0.973	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,287 associations by consensus.

Negative regulation of viral genome replication by PSME1 expression — SOFT_TISSUE

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