PSMD9

Across TCGA pan-cancer cohorts, PSMD9 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PSMD9’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PSMD9 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PSMD9 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, LSCC, and LUAD are the cancer types where PSMD9 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMD9 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.504	<.001	10	view →
LSCC	All	III,IV	−0.229	<.001	8	view →
LUAD	Female	All	−0.176	<.001	6	view →
PDAC	Male	All	−0.182	.012	5	view →
CCRCC	All	All	+0.067	.017	5	view →
OV	All	All	+1.110	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PSMD9–COAD

Open the COAD breakdown →