PSMD5

Across TCGA patient cohorts, PSMD5 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMD5-associated genes across cancer lineages are Gab2, Tuberin, and A-Raf_pS299. Each is linked with PSMD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMD5-to-partner and partner-to-PSMD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by PSMD5-low versus PSMD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMD5→partner) and Y-score (partner→PSMD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.366	+2.000	.006	.030	3	2
UCEC	Tuberin →	+0.360	+1.415	<.001	.046	3	2
UCEC	A-Raf_pS299 →	-0.123	-3.321	.005	.009	3	1
UCEC	IRS1 →	+0.167	+1.415	.031	.046	3	1
UCEC	JNK2 →	+0.205	+1.594	.005	.042	3	1
UCEC	Ku80 →	+0.219	+1.428	.013	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Gab2 by PSMD5 expression — UCEC

Explore this box plot interactively →