PSMD4

Across TCGA pan-cancer cohorts, PSMD4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PSMD4 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PSMD4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PSMD4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where PSMD4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.976	0.780	.020	24	view →
LUAD	OS	Median	All	0.613	0.901	<.001	21	view →
HNSC	DFS	Median	III,IV	0.924	0.662	.002	12	view →
PDAC	DFS	Quartile	All	0.846	0.746	.023	6	view →
LSCC	OS	Median	All	0.828	0.925	.017	3	view →
GBM	OS	Median	All	0.899	0.810	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PSMD4–UCEC (DFS)

Open the UCEC breakdown →