PSMD4

Across TCGA patient cohorts, PSMD4 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMD4-associated genes across cancer lineages are Rad50, p62 Lck ligand, and Rab11. Each is linked with PSMD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMD4-to-partner and partner-to-PSMD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by PSMD4-low versus PSMD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMD4→partner) and Y-score (partner→PSMD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.296	-3.321	.019	.010	2	2
UCEC	p62 Lck ligand →	+0.474	+3.321	.005	.010	2	1
UCEC	Rab11 →	-0.152	-3.321	.045	.010	2	1
UCEC	Di-Ras3 →	-0.188	-3.000	.015	.036	2	1
UCEC	Cyclin-B1 →	+0.594	+3.321	.043	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Rad50 by PSMD4 expression — UCEC

Explore this box plot interactively →