PSMD2

Across TCGA patient cohorts, PSMD2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMD2-associated genes across cancer lineages are eIF4E, MEK1, and PCNA. Each is linked with PSMD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMD2-to-partner and partner-to-PSMD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PSMD2-low versus PSMD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMD2→partner) and Y-score (partner→PSMD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.181	+2.459	.013	<.001	3	2
UCEC	MEK1 →	+0.506	+2.938	<.001	<.001	3	2
UCEC	PCNA →	+0.230	+2.906	.002	.001	3	2
UCEC	ASNS →	+0.360	+1.906	.004	.015	3	2
UCEC	ATM →	-0.409	-3.446	.009	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.667	+1.827	.001	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eIF4E by PSMD2 expression — UCEC

Explore this box plot interactively →