PSMD14

Across TCGA patient cohorts, PSMD14 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMD14-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and ERK2. Each is linked with PSMD14 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMD14-to-partner and partner-to-PSMD14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PSMD14-low versus PSMD14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMD14→partner) and Y-score (partner→PSMD14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.098	-3.295	.021	.009	3	1
UCEC	EGFR_pY1068 →	-0.230	-2.222	.031	.011	3	1
UCEC	ERK2 →	+0.167	+1.700	.041	.044	3	1
UCEC	Gab2 →	+0.316	+1.700	.037	.044	3	1
UCEC	JNK_pT183_Y185 →	-0.159	-2.209	.025	.011	3	1
UCEC	Ku80 →	+0.234	+1.713	.019	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

14-3-3_beta by PSMD14 expression — UCEC

Explore this box plot interactively →