PSMD11

Across TCGA patient cohorts, PSMD11 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMD11-associated genes across cancer lineages are MSH6, PCNA, and Cyclin-B1. Each is linked with PSMD11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMD11-to-partner and partner-to-PSMD11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by PSMD11-low versus PSMD11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMD11→partner) and Y-score (partner→PSMD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.268	-1.874	.027	.049	3	2
UCEC	PCNA →	+0.185	+2.115	.020	.017	3	2
UCEC	Cyclin-B1 →	+0.595	+3.459	.003	.005	3	2
UCEC	53BP1 →	+0.270	+2.000	.032	.029	3	2
UCEC	eIF4E →	+0.212	+3.700	.006	.001	3	1
UCEC	JNK2 →	+0.197	+2.009	.006	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MSH6 by PSMD11 expression — UCEC

Explore this box plot interactively →