PSMD11

Across TCGA cell cohorts, PSMD11 mutation is significantly associated with the RNA expression of many other genes, with 211 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PSMD11-associated genes across cancer lineages are COX4I2, SEPTIN3, and CNIH1. Each is linked with PSMD11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMD11-to-partner and partner-to-PSMD11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX4I2 grouped by PSMD11-low versus PSMD11-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMD11→partner) and Y-score (partner→PSMD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	COX4I2 →	+0.084	+5.813	<.001	<.001	3	1
LARGE_INTESTINE	SEPTIN3 →	+1.242	+3.299	.002	.004	3	1
LARGE_INTESTINE	CNIH1 →	+0.657	+3.299	<.001	.004	3	1
LARGE_INTESTINE	CA2 →	+2.140	+3.212	<.001	.006	3	1
LARGE_INTESTINE	B9D1 →	+0.789	+3.299	.001	.004	3	1
LARGE_INTESTINE	BAG2 →	+0.994	+3.212	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 211 associations by consensus.

COX4I2 by PSMD11 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →