PSMD10

Across TCGA pan-cancer cohorts, PSMD10 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PSMD10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PSMD10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PSMD10 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where PSMD10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMD10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.957	<.001	12	view →
KIRC	Female	All	+0.556	<.001	12	view →
COAD	Female	II,III,IV	+0.730	<.001	11	view →
LIHC	Male	All	+1.446	<.001	9	view →
BLCA	All	All	+0.481	<.001	9	view →
THCA	Male	III,IV	−0.439	.002	8	view →
BRCA	All	III,IV	+0.699	<.001	6	view →
STAD	All	II,III,IV	+0.631	<.001	6	view →
KIRP	All	II,III,IV	+0.531	<.001	6	view →
CHOL	All	All	+2.023	<.001	5	view →
ESCA	All	All	+0.682	.001	5	view →
LUSC	Male	All	+0.651	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PSMD10–HNSC

Open the HNSC breakdown →