PSMD1

Across TCGA patient cohorts, PSMD1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMD1-associated genes across cancer lineages are eIF4E, ASNS, and 4E-BP1. Each is linked with PSMD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSMD1-to-partner and partner-to-PSMD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PSMD1-low versus PSMD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMD1→partner) and Y-score (partner→PSMD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.159	+2.415	.027	.003	3	3
UCEC	ASNS →	+0.477	+2.115	<.001	.016	3	3
UCEC	4E-BP1 →	+0.393	+2.700	<.001	.005	3	3
UCEC	FASN →	+0.393	+1.678	.003	.021	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.392	+1.807	.023	.004	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.335	-2.906	.028	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eIF4E by PSMD1 expression — UCEC

Explore this box plot interactively →