PSMC6

Across TCGA pan-cancer cohorts, PSMC6 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PSMC6 data layer compared with 29 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PSMC6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PSMC6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where PSMC6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.945	0.632	.001	31	view →
LUAD	DFS	Quartile	All	0.368	0.888	<.001	27	view →
UCEC	DFS	Median	All	0.962	0.858	.018	2	view →
CCRCC	DFS	Quartile	All	0.942	0.762	.039	2	view →
PDAC	DFS	Quartile	III,IV	0.259	0.651	.026	2	view →
LSCC	DFS	Median	All	0.822	0.505	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PSMC6–HNSC (DFS)

Open the HNSC breakdown →