PSMC6

Across TCGA pan-cancer cohorts, PSMC6 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PSMC6’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PSMC6 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PSMC6 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

CCRCC, COAD, and LUAD are the cancer types where PSMC6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMC6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+0.139	<.001	11	view →
COAD	Male	All	+0.221	<.001	9	view →
LUAD	Female	II,III,IV	+0.182	<.001	9	view →
LSCC	Male	II,III,IV	+0.205	<.001	7	view →
HNSC	Male	All	−0.121	<.001	7	view →
PDAC	Male	All	+0.335	<.001	4	view →
OV	All	All	+0.221	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PSMC6–CCRCC

Open the CCRCC breakdown →