PSMC6

Across TCGA patient cohorts, PSMC6 mutation is significantly associated with the RNA expression of many other genes, with 1,454 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMC6-associated genes across cancer lineages are MIR2909, RN7SL210P, and RN7SKP39. Each is linked with PSMC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMC6-to-partner and partner-to-PSMC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR2909 grouped by PSMC6-low versus PSMC6-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC6→partner) and Y-score (partner→PSMC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR2909 →	+0.402	+4.758	<.001	.006	3	2
BRCA	RN7SL210P →	+0.344	+5.070	<.001	.008	3	2
BLCA	RN7SKP39 →	+0.084	+4.177	.003	.002	3	2
SKCM	RBM17P2 →	+0.061	+4.208	<.001	.003	3	2
BLCA	COX6CP7 →	+0.193	+3.910	<.001	.003	3	2
SKCM	RPL32P36 →	+0.198	+3.801	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,454 associations by consensus.

MIR2909 by PSMC6 expression — LIHC

Explore this box plot interactively →