PSMC6

Across TCGA patient cohorts, PSMC6 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMC6-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and Fibronectin. Each is linked with PSMC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMC6-to-partner and partner-to-PSMC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PSMC6-low versus PSMC6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC6→partner) and Y-score (partner→PSMC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.098	-1.673	.006	.040	3	1
UCEC	eIF4E →	+0.181	+2.807	.017	<.001	3	1
UCEC	Fibronectin →	-0.280	-1.755	.018	.013	3	1
UCEC	FoxM1 →	+0.196	+1.925	.036	.005	3	1
UCEC	ACC_pS79 →	+0.322	+2.584	.009	.010	3	1
UCEC	GATA3 →	-0.162	-1.787	.017	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

14-3-3_beta by PSMC6 expression — UCEC

Explore this box plot interactively →