PSMC5

Across TCGA pan-cancer cohorts, PSMC5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PSMC5 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PSMC5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PSMC5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where PSMC5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.630	0.840	.003	40	view →
CCRCC	DFS	Median	All	1.000	0.729	.017	16	view →
HNSC	OS	Median	All	1.000	0.449	.023	7	view →
COAD	DFS	Median	III,IV	1.000	0.899	.046	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PSMC5–LUAD (OS)

Open the LUAD breakdown →