PSMC5

Across TCGA patient cohorts, PSMC5 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMC5-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and ERK2. Each is linked with PSMC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMC5-to-partner and partner-to-PSMC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PSMC5-low versus PSMC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC5→partner) and Y-score (partner→PSMC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.273	-1.807	.008	.027	3	1
UCEC	A-Raf_pS299 →	-0.123	-3.459	.012	.005	3	1
UCEC	ERK2 →	+0.242	+3.459	.002	.005	3	1
UCEC	MSH2 →	-0.339	-3.558	<.001	.002	3	1
UCEC	MSH6 →	-0.376	-2.459	.005	.018	3	1
UCEC	mTOR_pS2448 →	-0.144	-2.302	.019	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by PSMC5 expression — UCEC

Explore this box plot interactively →