PSMC5

Across TCGA cell cohorts, PSMC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,602 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PSMC5-associated GO terms across cancer lineages are Mitotic spindle elongation, Mitotic spindle midzone assembly, and Positive regulation of nuclear cell cycle DNA replication. Each is linked with PSMC5 in more than 14 cancer types. Because this analysis shows association rather than direction, both PSMC5-to-partner and partner-to-PSMC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic spindle elongation grouped by PSMC5-low versus PSMC5-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC5→partner) and Y-score (partner→PSMC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Mitotic spindle elongation →	+0.212	+0.622	<.001	<.001	3	15
SKIN	Mitotic spindle midzone assembly →	+0.212	+0.622	<.001	<.001	3	15
PANCREAS	Positive regulation of nuclear cell cycle DNA replication →	+0.124	+0.709	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle process →	+0.066	+0.792	.001	.001	3	13
PANCREAS	Positive regulation of mitotic cell cycle phase transition →	+0.092	+0.753	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) →	+0.102	+0.832	.002	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,602 associations by consensus.

Mitotic spindle elongation by PSMC5 expression — SKIN

Explore this box plot interactively →