PSMC4

Across TCGA patient cohorts, PSMC4 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMC4-associated genes across cancer lineages are STAT5a, Cyclin-B1, and 14-3-3_beta. Each is linked with PSMC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMC4-to-partner and partner-to-PSMC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT5a grouped by PSMC4-low versus PSMC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC4→partner) and Y-score (partner→PSMC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT5a →	+0.308	+1.874	.040	.049	3	2
UCEC	Cyclin-B1 →	+0.442	+1.765	.036	.014	3	2
UCEC	14-3-3_beta →	-0.087	-1.847	.021	.049	3	1
UCEC	A-Raf_pS299 →	-0.144	-2.115	.001	.017	3	1
UCEC	ERK2 →	+0.270	+2.662	<.001	<.001	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.433	+1.710	.023	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

STAT5a by PSMC4 expression — UCEC

Explore this box plot interactively →