PSMC4

Across TCGA cell cohorts, PSMC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,570 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PSMC4-associated GO terms across cancer lineages are Transcription initiation at RNA polymerase I promoter, Spliceosomal snRNP assembly, and Nuclear histone mRNA catabolic process. Each is linked with PSMC4 in more than 12 cancer types. Because this analysis shows association rather than direction, both PSMC4-to-partner and partner-to-PSMC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription initiation at RNA polymerase I promoter grouped by PSMC4-low versus PSMC4-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC4→partner) and Y-score (partner→PSMC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Transcription initiation at RNA polymerase I promoter →	+0.151	+1.135	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Spliceosomal snRNP assembly →	+0.079	+0.613	.007	.003	2	13
PANCREAS	Nuclear histone mRNA catabolic process →	+0.110	+0.808	<.001	<.001	3	11
BLOOD_Myeloma	Peptidyl-proline modification →	+0.112	+0.814	<.001	<.001	3	11
BLOOD_Lymphoma	rRNA transcription →	+0.100	+0.883	<.001	<.001	3	10
SKIN	DNA replication initiation →	+0.117	+0.578	<.001	.005	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,570 associations by consensus.

Transcription initiation at RNA polymerase I promoter by PSMC4 expression — BLOOD_Lymphoma

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