PSMC3IP

Across TCGA patient cohorts, PSMC3IP mutation is significantly associated with the RNA expression of many other genes, with 313 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMC3IP-associated genes across cancer lineages are EIF4A3P1, SQSTM1P1, and DOC2B. Each is linked with PSMC3IP in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMC3IP-to-partner and partner-to-PSMC3IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF4A3P1 grouped by PSMC3IP-low versus PSMC3IP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC3IP→partner) and Y-score (partner→PSMC3IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF4A3P1 →	+0.140	+2.563	.002	.005	3	2
UCEC	SQSTM1P1 →	+0.088	+3.031	<.001	.003	3	1
UCEC	DOC2B →	-1.430	-3.459	<.001	.005	3	1
UCEC	OR5BP1P →	+0.105	+3.923	<.001	.009	3	1
UCEC	LINC00547 →	+0.112	+3.148	.001	<.001	3	1
UCEC	VN1R7P →	+0.301	+3.023	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 313 associations by consensus.

EIF4A3P1 by PSMC3IP expression — UCEC

Explore this box plot interactively →