PSMC3IP

Across TCGA patient cohorts, PSMC3IP mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMC3IP-associated genes across cancer lineages are Akt_pT308, Annexin-1, and 14-3-3_beta. Each is linked with PSMC3IP in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMC3IP-to-partner and partner-to-PSMC3IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by PSMC3IP-low versus PSMC3IP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC3IP→partner) and Y-score (partner→PSMC3IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.745	+3.169	.031	.020	3	1
UCEC	Annexin-1 →	+0.634	+2.827	.028	.035	3	1
UCEC	14-3-3_beta →	-0.181	-3.156	.001	.020	1	1
UCEC	Myosin-IIa_pS1943 →	+0.239	+3.183	.035	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Akt_pT308 by PSMC3IP expression — UCEC

Explore this box plot interactively →