PSMC3

Across TCGA pan-cancer cohorts, PSMC3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PSMC3 data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PSMC3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PSMC3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

LUAD, HNSC, and CCRCC are the cancer types where PSMC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.375	0.759	.001	39	view →
HNSC	DFS	Median	III,IV	0.760	0.475	.001	37	view →
CCRCC	DFS	Median	IV	0.781	0.220	.017	20	view →
GBM	DFS	Median	All	0.647	0.843	.011	9	view →
PDAC	OS	Median	III,IV	0.612	0.879	.009	5	view →
UCEC	DFS	Median	All	0.933	0.789	.034	4	view →
LSCC	OS	Median	II,III,IV	1.000	0.888	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PSMC3–LUAD (DFS)

Open the LUAD breakdown →