PSMC3

Across TCGA patient cohorts, PSMC3 mutation is significantly associated with the RNA expression of many other genes, with 708 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMC3-associated genes across cancer lineages are TUBGCP5, COX5A, and GINS3. Each is linked with PSMC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMC3-to-partner and partner-to-PSMC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBGCP5 grouped by PSMC3-low versus PSMC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC3→partner) and Y-score (partner→PSMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TUBGCP5 →	+0.432	+3.332	.005	.005	3	2
UCEC	COX5A →	+0.454	+3.847	.002	<.001	3	2
UCEC	GINS3 →	+0.509	+2.928	.003	.001	3	2
UCEC	FANCA →	+0.661	+2.906	<.001	.002	3	2
UCEC	LONP1 →	+0.537	+2.233	.004	.006	3	2
UCEC	PRIM1 →	+0.646	+3.475	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 708 associations by consensus.

TUBGCP5 by PSMC3 expression — UCEC

Explore this box plot interactively →