PSMC3

Across TCGA patient cohorts, PSMC3 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMC3-associated genes across cancer lineages are MEK1, PCNA, and EGFR_pY1068. Each is linked with PSMC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMC3-to-partner and partner-to-PSMC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PSMC3-low versus PSMC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC3→partner) and Y-score (partner→PSMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.427	+3.321	.009	.010	3	2
UCEC	PCNA →	+0.279	+3.459	.004	.005	3	2
UCEC	EGFR_pY1068 →	-0.235	-2.000	.037	.032	3	1
UCEC	A-Raf_pS299 →	-0.156	-3.000	.003	.036	3	1
UCEC	FoxM1 →	+0.347	+2.700	.002	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.180	-2.687	.018	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MEK1 by PSMC3 expression — UCEC

Explore this box plot interactively →