PSMC2P2

Across TCGA pan-cancer cohorts, PSMC2P2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PSMC2P2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PSMC2P2 RNA is repressed in tumor relative to normal tissue. In most cancer types PSMC2P2 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and STAD are the cancer types where PSMC2P2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMC2P2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.025	<.001	7	view →
KICH	All	II,III,IV	−0.022	.040	2	view →
STAD	All	All	+0.019	.025	2	view →
KIRP	Male	All	−0.030	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PSMC2P2–KIRC

Open the KIRC breakdown →