PSMC2

Across TCGA patient cohorts, PSMC2 mutation is significantly associated with the RNA expression of many other genes, with 1,868 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMC2-associated genes across cancer lineages are RPL7P29, SLC25A5P9, and RPL23AP84. Each is linked with PSMC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMC2-to-partner and partner-to-PSMC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL7P29 grouped by PSMC2-low versus PSMC2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC2→partner) and Y-score (partner→PSMC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPL7P29 →	+0.225	+4.478	<.001	.005	3	2
READ	SLC25A5P9 →	+0.144	+4.724	.001	.003	3	2
KIRP	RPL23AP84 →	+0.139	+5.264	<.001	.006	3	2
READ	RNU6-226P →	+0.326	+5.681	<.001	.001	3	2
READ	OR12D1 →	+0.081	+5.257	<.001	.002	3	2
UCEC	H4C12 →	+0.420	+1.985	.009	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,868 associations by consensus.

RPL7P29 by PSMC2 expression — COAD

Explore this box plot interactively →