PSMC2

Across TCGA cell cohorts, PSMC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,635 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PSMC2-associated GO terms across cancer lineages are Positive regulation of chromosome segregation, Spindle elongation, and Peptidyl-glutamic acid carboxylation. Each is linked with PSMC2 in more than 13 cancer types. Because this analysis shows association rather than direction, both PSMC2-to-partner and partner-to-PSMC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of chromosome segregation grouped by PSMC2-low versus PSMC2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC2→partner) and Y-score (partner→PSMC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of chromosome segregation →	+0.151	+0.862	<.001	<.001	3	14
BONE	Spindle elongation →	+0.185	+0.544	.002	.002	3	13
LUNG_NSCLC_LUAD	Peptidyl-glutamic acid carboxylation →	+0.111	+0.546	<.001	.002	3	12
LUNG_NSCLC_LUAD	Protein carboxylation →	+0.111	+0.546	<.001	.002	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.127	+0.774	.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome separation →	+0.127	+0.774	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,635 associations by consensus.

Positive regulation of chromosome segregation by PSMC2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →