PSMC1

Across TCGA pan-cancer cohorts, PSMC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PSMC1 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PSMC1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PSMC1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where PSMC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.728	0.964	.006	12	view →
CCRCC	OS	Quartile	III,IV	0.554	0.862	.009	9	view →
HNSC	DFS	Tertile	III,IV	0.888	0.688	.033	7	view →
UCEC	OS	Median	All	0.986	0.915	.049	2	view →
LSCC	DFS	Quartile	II,III,IV	0.555	1.000	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PSMC1–LUAD (OS)

Open the LUAD breakdown →