PSMC1

Across TCGA patient cohorts, PSMC1 mutation is significantly associated with the RNA expression of many other genes, with 285 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMC1-associated genes across cancer lineages are RNA5SP305, RNA5SP303, and MIR769. Each is linked with PSMC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSMC1-to-partner and partner-to-PSMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP305 grouped by PSMC1-low versus PSMC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC1→partner) and Y-score (partner→PSMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNA5SP305 →	+0.721	+5.037	.001	.002	3	3
CESC	RNA5SP303 →	+0.373	+4.969	<.001	.004	3	2
CESC	MIR769 →	+0.395	+4.934	<.001	.002	3	2
CESC	AGBL4-AS1 →	+0.068	+4.539	<.001	.008	3	2
COAD	BPY2DP →	+0.359	+6.409	<.001	<.001	3	2
UCEC	NOL12 →	+0.427	+2.732	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 285 associations by consensus.

RNA5SP305 by PSMC1 expression — COAD

Explore this box plot interactively →