PSMC1

Across TCGA patient cohorts, PSMC1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMC1-associated genes across cancer lineages are PRAS40_pT246, Bak, and CD31. Each is linked with PSMC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMC1-to-partner and partner-to-PSMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by PSMC1-low versus PSMC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC1→partner) and Y-score (partner→PSMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.217	+2.321	.008	.034	3	1
UCEC	Bak →	+0.272	+2.999	.024	.035	3	1
UCEC	CD31 →	-0.163	-3.311	.022	.010	3	1
UCEC	53BP1 →	+0.339	+2.459	.040	.020	3	1
UCEC	14-3-3_beta →	-0.124	-3.149	.010	.019	2	1
UCEC	P-Cadherin →	-0.184	-2.446	.008	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PRAS40_pT246 by PSMC1 expression — UCEC

Explore this box plot interactively →