PSMC1

Across TCGA cell cohorts, PSMC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,780 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PSMC1-associated GO terms across cancer lineages are Regulation of chromosome separation, Positive regulation of cell cycle process, and Positive regulation of spindle checkpoint. Each is linked with PSMC1 in more than 16 cancer types. Because this analysis shows association rather than direction, both PSMC1-to-partner and partner-to-PSMC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome separation grouped by PSMC1-low versus PSMC1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMC1→partner) and Y-score (partner→PSMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of chromosome separation →	+0.148	+0.772	<.001	.001	3	17
PANCREAS	Positive regulation of cell cycle process →	+0.083	+0.813	.005	.006	3	16
OESOPHAGUS	Positive regulation of spindle checkpoint →	+0.139	+0.670	.001	.005	3	16
OESOPHAGUS	Positive regulation of mitotic cell cycle spindle assembly checkpoint →	+0.139	+0.670	.001	.005	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mitotic cell cycle phase transition →	+0.091	+1.473	<.001	<.001	3	15
SKIN	Positive regulation of cell cycle →	+0.072	+0.662	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,780 associations by consensus.

Regulation of chromosome separation by PSMC1 expression — KIDNEY

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