PSMB9

Across TCGA patient cohorts, PSMB9 mutation is significantly associated with the RNA expression of many other genes, with 295 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMB9-associated genes across cancer lineages are DBF4P3, OTOP1, and PGBD4P2. Each is linked with PSMB9 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMB9-to-partner and partner-to-PSMB9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DBF4P3 grouped by PSMB9-low versus PSMB9-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMB9→partner) and Y-score (partner→PSMB9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	DBF4P3 →	+0.070	+6.276	<.001	<.001	3	2
UCEC	OTOP1 →	+0.980	+2.298	<.001	.009	3	2
READ	PGBD4P2 →	+0.121	+5.257	<.001	.002	3	1
UCEC	ARRDC3-AS1 →	+0.291	+3.480	.007	.002	3	1
READ	IAPP →	+0.069	+4.361	<.001	.006	3	1
READ	ADAM30 →	+0.014	+4.653	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 295 associations by consensus.

DBF4P3 by PSMB9 expression — READ

Explore this box plot interactively →