Across TCGA pan-cancer cohorts, PSMB8 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PSMB8 data layer compared with 20 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PSMB8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PSMB8 expression acts as an unfavorable survival marker.

HNSC and SKCM are the cancer types where PSMB8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.051	0.751	<.001	48	view →
SKCM	DFS	Median	III,IV	0.088	0.613	.018	8	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: PSMB8 tumor-vs-normal RNA expression · all PSMB8 data types