Across TCGA patient cohorts, PSMB8 mutation is significantly associated with the RNA expression of many other genes, with 2,890 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMB8-associated genes across cancer lineages are RNA5SP45, RNA5SP211, and RNA5SP422. Each is linked with PSMB8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMB8-to-partner and partner-to-PSMB8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMB8→partner) and Y-score (partner→PSMB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP45 →	+0.210	+4.897	<.001	.002	3	2
BLCA	RNA5SP211 →	+0.215	+4.433	<.001	.007	3	2
UCEC	RNA5SP422 →	+0.781	+2.308	<.001	.002	3	2
UCEC	RANP3 →	+0.200	+2.517	.009	<.001	3	2
LUSC	RNA5SP80 →	+0.236	+4.393	<.001	.008	3	2
COAD	ARHGEF7-IT1 →	+0.245	+5.374	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,890 associations by consensus.

Exploration

PSMB8 survival (RNA) · tumor vs normal (RNA) · all PSMB8 data types